Reacción #10537

Ecuación de reacción

methyl 9-{(2R,3R,4R,5S)-3,4-bis(benzoyloxy)-5-[(ethylamino)carbonyl]-tetrahydro-2-furanyl}-6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate

sodium carbonate

→

title compound

Rendimiento 98.0%

Methyl 6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxylate

Rendimiento 98.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroSolvent was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue taken up in a mixture of dichloromethane:methanol (95:5, by volume, 60 ml)
3. 3
   FiltraciónInorganic salts were filtered off
4. 4
   Otrothe filtrate evaporated under reduced pressure
5. 5
   OtroThe residue was triturated with diethyl ether
6. 6
   Filtraciónfiltered off
7. 7
   Otrodried

Procedimiento

A solution of methyl 9-{(2R,3R,4R,5S)-3,4-bis(benzoyloxy)-5-[(ethylamino)carbonyl]-tetrahydro-2-furanyl}-6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate (Preparation 8) (3.4 g, 4.5 mmol) and sodium carbonate (50 mg) in dry methanol (60 ml) was stirred at room temperature for four hours. Solvent was removed under reduced pressure and the residue taken up in a mixture of dichloromethane:methanol (95:5, by volume, 60 ml). Inorganic salts were filtered off and the filtrate evaporated under reduced pressure. The residue was triturated with diethyl ether, filtered off and dried to yield the title compound as a white solid, (2.4 g, 98%).

Fuente