Reacción #1045

Ecuación de reacción

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

Rendimiento 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

Rendimiento 14.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for overnight
2. 2
   OtroThe residue obtained
3. 3
   Otroafter evaporation of the solvent
4. 4
   Otrowas chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

Procedimiento

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

Fuente