Reacción #1044

Ecuación de reacción

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

Rendimiento 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

Rendimiento 94.2%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   Filtraciónfiltered
3. 3
   OtroThe residue obtained
4. 4
   Otroafter evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   Filtraciónfiltered
7. 7
   OtroEvaporation of the solvent

Procedimiento

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

Fuente