Reacción #1042

Ecuación de reacción

3,4,4-trifluoro-3-butenoyl chloride

2-amino-4,6-dimethoxypyrimidine

potassium carbonate

→

title compound

Rendimiento 10.7%

2-(3,4,4-trifluoro-1-oxo-3-butenyl)amino-4,6-dimethoxy-pyrimidine

Rendimiento 10.7%

Disolventes

dichloromethane

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe reaction mixture was stirred in cold for 10 min
2. 2
   LavadoThe organic layer was washed with 3N HCl (2×25 mL), saturated sodium bicarbonate (25 mL) and brine
3. 3
   Otrodried
4. 4
   OtroEvaporation of the solvent

Procedimiento

To an ice-cooled stirred suspension of 2-amino-4,6-dimethoxypyrimidine (1.55 g, 10 mmol) in dichloromethane (50 mL) and potassium carbonate (2.76 g, 20 mmol) in water (20 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (3.17 g, 20 mmol). The reaction mixture was stirred in cold for 10 min and at r.t. for 15 min. The organic layer was washed with 3N HCl (2×25 mL), saturated sodium bicarbonate (25 mL) and brine, and dried. Evaporation of the solvent gave 0.296 g (10%) of the title compound as a white solid. m.p. 127°-130° C.

Fuente