Reacción #1038

Ecuación de reacción

3,4,4-trifluoro-3-buten-1-ol

Jones reagent

→

3,4,4-trifluoro-3-butenoic

3,4,4-trifiuoro-3-butenoic acid

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroare at a temperature of about 51°-54° C

Procedimiento

The first method involves hydrolysis of 4-bromo-1,1,2-trifluoro-1-butene (II) with water in the presence of N-methyl pyrrolidinone to give 3,4,4-trifiuoro-3-buten-1-ol (III), followed by Jones oxidation under conditions not previously known. These conditions are at a temperature of about 51°-54° C. In addition, the 3,4,4-trifluoro-3-buten-1-ol in acetone solvent and the Jones reagent are added to the reaction vessel simultaneously to afford 3,4,4-trifluoro-3-butenoic (IV) acid in 52% overall yield. ##STR4##

Fuente