Reacción #10321

Ecuación de reacción

1-(2-thienylthio)acetone

→

3-methylthieno[2,3-b]thiophene

Rendimiento 42.0%

Disolventes

chlorobenzene

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was heated
2. 2
   Temperaturato reflux overnight
3. 3
   OtroThe chlorobenzene layer was decanted off
4. 4
   workup.ADDITIONfurther chlorobenzene (15 mL x2) was added to the polyphosphoric acid residue
5. 5
   Temperaturaat reflux for 30 minutes
6. 6
   ConcentraciónThe combined chlorobenzene extracts were concentrated in vacuo
7. 7
   Otropurified by flash column chromatography on silica
8. 8
   Lavadoeluting with 40% dichloromethane/isohexane

Procedimiento

A 1M solution of 1-(2-thienylthio)acetone (2.6 g, 15.1 mmol) in chlorobenzene (15 mL) was heated to 110° C. under nitrogen and hot polyphosphoric acid (3 mL) was added. The reaction was heated to reflux overnight. The chlorobenzene layer was decanted off and further chlorobenzene (15 mL x2) was added to the polyphosphoric acid residue and stirred at reflux for 30 minutes. The combined chlorobenzene extracts were concentrated in vacuo and purified by flash column chromatography on silica, eluting with 40% dichloromethane/isohexane, to give 3-methylthieno[2,3-b]thiophene (0.97 g, 42%). 1H NMR (500 MHz, CDCl3) δ 7.34 (1H, dd, J=1.0, 5.2 Hz), 7.16 (1H, d, J=5.2 Hz), 6.94 (1H, t, J=1.1 Hz), 2.40 (3H, d, J=1.1 Hz).

Fuente