Reacción #10267

Ecuación de reacción

NaOH

acetaldehyde

O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride

NaOH

→

2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime

Rendimiento 100.0%

Disolventes

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with dichloromethane
2. 2
   SecadoThe organic layer was dried (Na2SO4)
3. 3
   Concentraciónconcentrated in vacuo

Procedimiento

A mixture of acetaldehyde (0.1 mL of a 50 wt % soln. in water), O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride (0.14 g), NaOH (2N, 0.64 mL) and water (5 mL) was stirred at room temperature overnight. The solution was made basic with NaOH (1N) and extracted with dichloromethane. The organic layer was dried (Na2SO4), and concentrated in vacuo to afford 2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime (0.13 g, ˜100%), which was used as such.

Fuente