Reacción #1023

Ecuación de reacción

2-amino-1-propanol

sodium hydride

4-chloropyridine hydrochloride

→

desired product

Rendimiento 30.2%

1-methyl-2-(4-pyridyloxy)ethylamine

Rendimiento 30.2%

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe mixture was stirred for 20 hours at room temperature
2. 2
   OtroAfter completion of the reaction
3. 3
   Filtraciónthe solids were filtered off
4. 4
   OtroThe solvent in the filtrate was removed under reduced pressure
5. 5
   OtroThe residue was purified by column chromatography on silica gel

Procedimiento

6.2 g of 2-amino-1-propanol was added dropwise to a stirred mixture of 4.0 g of 60% sodium hydride and 50 mL of N,N-dimethylformamide at 5° C.-10° C. After the reaction mixture was stirred for 30 minutes, 12.5 g of 4-chloropyridine hydrochloride in limited amounts was added to the reaction mixture. The mixture was stirred for 20 hours at room temperature. After completion of the reaction, the solids were filtered off. The solvent in the filtrate was removed under reduced pressure. The residue was purified by column chromatography on silica gel to obtain 3.8 g of the desired product (yield: 30%). Refractive index: 1.5469.

Fuente