Reacción #10201

Ecuación de reacción

1-(4-Acetyl-5-hydroxy-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

hydroxylamine HCl

sodium acetate

→

oil

Rendimiento 93.0%

2,2,2-Trifluoro-1-[4-hydroxy-5-(1-hydroxyimino-ethyl)-10-aza-tricyclo[6.3.1.02,7]-dodeca-2(7),3,5-trien-10-yl]-ethanone

Rendimiento 93.0%

Disolventes

methanol

H2O

H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled
2. 2
   Extracciónextracted with ethyl acetate which
3. 3
   Secadowas dried (Na2SO4)
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

1-(4-Acetyl-5-hydroxy-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone (190 mg, 0.605 mmol), hydroxylamine HCl (99 mg, 1.21 mmol) and sodium acetate (118 mg, 1.21 mmol) were combined in methanol (4 mL) and H2O (1 mL) and warmed to 65° C. for 18 hours. The mixture was cooled, diluted with H2O and extracted with ethyl acetate which was dried (Na2SO4), filtered and concentrated to provide a yellow oil (177 mg, 93%).

Fuente