Reacción #10197

Ecuación de reacción

NaHCO3

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

AcCl

aluminum chloride

→

1-(4-Acetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

Disolventes

DCE

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGAfter stirring 20 minutes the mixture
2. 2
   Extracciónwas extracted with CH2Cl2 (3×30 mL)
3. 3
   OtroThe organic layer was dried through a cotton plug
4. 4
   Concentraciónthen concentrated to a orange-yellow oil (255 mg, 86%)

Procedimiento

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone (253 mg, 1.0 mmol) and AcCl (0.68 mL, 10 mmol) were dissolved in DCE (3 mL) and treated with aluminum chloride (AlCl3) (667 mg, 5.0 mmol). The resulting yellow mixture was stirred for 30 minutes then poured over ice and saturated aqueous NaHCO3 solution. After stirring 20 minutes the mixture was extracted with CH2Cl2 (3×30 mL). The organic layer was dried through a cotton plug then concentrated to a orange-yellow oil (255 mg, 86%).

Fuente