Reacción #10180

Ecuación de reacción

hydrochloric acid

9-oxo-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene

sodium borohydride

p-toluenesulfonic acid monohydrate

boron trifluoride diethyl etherate

→

title compound

10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene tosylate

Disolventes

tetrahydrofuran

isopropanol

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaHeating
2. 2
   Temperaturaa reflux for 12 hours
3. 3
   TemperaturaThe reaction mixture was then cooled to room temperature
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   workup.ADDITIONThe residue was diluted with 20 mL of 20% aqueous sodium hydroxide
6. 6
   Extracciónthe aqueous layer was extracted with another 30 mL of methyl-tert-butyl ether
7. 7
   LavadoThe combined organic layers were washed with 40 mL of a saturated aqueous sodium chloride solution
8. 8
   Secadodried over anhydrous sodium sulfate
9. 9
   TemperaturaThe solution was heated until homogeneous and
10. 10
    Temperaturato gradually cool to room temperature
11. 11
    workup.STIRRINGwith stirring

Procedimiento

To a solution of 1.38 g of 9-oxo-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene (8.00 mmol, 1 equivalent) in 8 mL of tetrahydrofuran was added 603 mg of sodium borohydride (16.0 mmol, 2.0 equivalent) followed by slow addition of 2.77 mL of boron trifluoride diethyl etherate (21.6 mmol, 2.7 equivalent). Once the effervescence subsided, the reaction mixture was heated to 50° C. for 5 hours. The reaction was then cooled to room temperature for addition of 10 mL of methanol (added dropwise at first) and 0.125 mL of concentrated hydrochloric acid. Heating was resumed at a reflux for 12 hours. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The residue was diluted with 20 mL of 20% aqueous sodium hydroxide followed by 30 mL of methyl-tert-butyl ether. The mixture was stirred for 30 minutes and then the aqueous layer was extracted with another 30 mL of methyl-tert-butyl ether. The combined organic layers were washed with 40 mL of a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. After concentrating in vacuo, 1.67 g of p-toluenesulfonic acid monohydrate (8.80 mmol, 1.1 equivalent) was added with 20 mL of isopropanol. The solution was heated until homogeneous and then allowed to gradually cool to room temperature with stirring. White crystals of the title compound formed and were collected by filtration (2.17 g, 81%). mp: 207–208° C.; 1H NMR (400 MHz, CD3OD): δ 7.69 (d, J=7.9 Hz, 2H), 7.43–7.32 (m, 4H), 7.23 (d, J=7.9 Hz, 2H), 3.37 (d, J=11.2 Hz, 4H), 3.30 (bs, 2H), 3.15 (d, J=12.4 Hz, 2H) 2.36 (s, 3H), 2.40–2.35 (m, 1H), 2.08 (d, J=11.2 Hz, 1H); 13C NMR (100 MHz, CD3OD): δ 140.8, 140.5, 139.1, 127.2, 127.2, 124.3, 122.3, 45.1, 39.7, 37.3, 18.7; IR (KBr, cm−1): 3438, 3021, 2958, 2822, 2758, 2719, 2683, 2611, 2424, 1925, 1606, 1497, 1473, 1428, 1339, 1302, 1259, 1228, 1219, 1176, 1160, 1137, 1122, 1087, 1078, 945, 914, 876, 847, 829, 818, 801, 710, 492; Anal. Calcd for C18H21NO3S: C, 65.23; H, 6.39; N, 4.23; Found: C, 65.05; H, 6.48; N, 4.26.

Fuente