Reacción #1012567

Ecuación de reacción

sodium carbonate

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-iodobenzamide

3,4-dimethyl phenylboronic acid

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-3′,4′-dimethylbiphenyl-2-carboxamide

Rendimiento 63.5%

Disolventes

water

dimethoxyethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroN-(2-(5-chloro-1H-indol-3-yl)ethyl)-3′,4′-dimethylbiphenyl-2-carboxamide was prepared

Procedimiento

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-3′,4′-dimethylbiphenyl-2-carboxamide was prepared according to method B with N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-iodobenzamide (0.075 g; 0.176 mmol), 3,4-dimethyl phenylboronic acid (0.028 g; 0.180 mmol), tetrakis(triphenylphosphine)palladium (0.010 g; 0.009 mmol), sodium carbonate (0.037 g; 0.353 mmol), in dimethoxyethane (3 mL) and water (1 mL), irradiated in a microwave oven at 130° C. for 15 minutes. Flash chromatography on silica gel (eluent 10 to 80% ethyl acetate in heptane) furnished 0.045 g (63%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-3′,4′-dimethylbiphenyl-2-carboxamide as a white solid.

Fuente