Reacción #1012290

Ecuación de reacción

(3R)-1,1,3-trimethyl-4-aminoindane

hydrogen

hydrogen

→

1,1,3-trimethyl-4-aminoindane

Disolventes

toluene

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroobtaining a mixture
2. 2
   OtroThe reaction vessel was sealed
3. 3
   workup.STIRRINGthe mixture was stirred at an internal temperature of 60° C
4. 4
   workup.STIRRINGthe mixture was stirred at an internal temperature of 150° C.
5. 5
   workup.WAITan internal pressure of 0.1 MPa for 14 hours
6. 6
   Otroobtaining a reaction mixture
7. 7
   OtroThe obtained reaction mixture
8. 8
   Temperaturawas cooled
9. 9
   Filtraciónfiltered
10. 10
    LavadoThe obtained solid was washed with 150 parts by weight of toluene
11. 11
    OtroThe washing liquid recovered
12. 12
    Lavadoafter washing
13. 13
    Otrothe filtrate obtained by filtration

Procedimiento

2.88 parts by weight of the recovered palladium-carbon and 0.64 part, by weight of fresh 5% palladium-carbon (E-type, manufactured by N. E. Chemcat Corporation) were charged into an autoclave reaction vessel, and 104.0 parts by weight of (3R)-1,1,3-trimethyl-4-aminoindane (optical purity of 67.0% ee) and 1.5 parts by weight of toluene were added thereto, thereby obtaining a mixture. The reaction vessel was sealed and the gas in the reaction vessel was replaced with nitrogen. While the mixture was stirred, into the reaction vessel was charged hydrogen until the internal pressure of hydrogen in the reaction vessel reached 0.5 MPa, and the mixture was stirred at an internal temperature of 60° C. After 1 hour, the gas in the reaction vessel was replaced with nitrogen, and the mixture was stirred at an internal temperature of 150° C. and an internal pressure of 0.1 MPa for 14 hours, thereby obtaining a reaction mixture. The obtained reaction mixture was cooled and filtered using Celite. The obtained solid was washed with 150 parts by weight of toluene. The washing liquid recovered after washing and the filtrate obtained by filtration were combined to obtain a solution of 244.6 parts by weight of 1,1,3-trimethyl-4-aminoindane in toluene. The combined 1,1,3-trimethyl-4-aminoindane had an optical purity of 0.11% ee and a recovery rate of 98.5%.

Fuente