Reacción #1010535

Ecuación de reacción

hydrazinecarboximidamide carbonic acid salt

2-methylbenzoyl chloride

→

2-(2-methylbenzoyl)hydrazinecarboximidamide

Rendimiento 35.0%

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated under vacuum
2. 2
   workup.ADDITIONdiluted with water (30 mL)
3. 3
   Filtraciónthe solid was collected by filtration
4. 4
   Lavadowashed with water (20 mL)

Procedimiento

To a solution of hydrazinecarboximidamide carbonic acid salt (12.0 g, 1.2 eq) in pyridine (100 mL) was added 2-methylbenzoyl chloride (crude afforded in step 1, 1.0 eq) dropwise at 0° C. The mixture was stirred overnight at room temperature. The reaction mixture was concentrated under vacuum, diluted with water (30 mL), adjusted to pH 12 with NaOH (aq), and the solid was collected by filtration and washed with water (20 mL) to afford 2-(2-methylbenzoyl)hydrazinecarboximidamide (5.0 g, 35% of two steps) as a white solid.

Fuente