Reacción #1010531

Ecuación de reacción

2-chlorobenzoyl chloride

hydrazinecarboximidamide carbonic acid salt

dichloromethane

→

2-(2-Chlorobenzoyl)hydrazinecarboximidamide

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthe resulting mixture was concentrated under vacuum
2. 2
   OtroThe residue was purified via silica gel column (ethyl acetate/petroleum ether (10/1))
3. 3
   Otroresulting in 3 g (22%) of 2-(2-chlorobenzoyl)hydrazinecarboximidamide as yellow oil

Procedimiento

A mixture of 2-chlorobenzoyl chloride (10 g, 60 mmol, 1.00 equiv) and hydrazinecarboximidamide carbonic acid salt (11.6 g, 85 mmol, 1.49 equiv) in pyridine (10 mL) and dichloromethane (100 g, 1.18 mol, 41.21 equiv) was stirred for 3 h at 25° C. After the reaction was completed, the resulting mixture was concentrated under vacuum. The residue was purified via silica gel column (ethyl acetate/petroleum ether (10/1)) resulting in 3 g (22%) of 2-(2-chlorobenzoyl)hydrazinecarboximidamide as yellow oil.

Fuente