Reacción #1010520

Ecuación de reacción

hydrazinecarboximidamide bicarbonate salt

4-chlorobenzoyl chloride

→

2-(4-chlorobenzoyl)hydrazinecarboximidamide

Disolventes

pyridine

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthe resulting mixture was concentrated under vacuum
2. 2
   Otroquenched by the addition of water (20 ml)
3. 3
   FiltraciónThe product was collected by filtration
4. 4
   Otrodried

Procedimiento

To a solution of hydrazinecarboximidamide bicarbonate salt (2.3 g, 31.05 mmol) in pyridine (70 ml) was added dropwise 4-chlorobenzoyl chloride (4.5 g, crude) in DCM (20 ml). After stirring overnight at 15° C., the resulting mixture was concentrated under vacuum, quenched by the addition of water (20 ml) and adjusted to pH 13 with sodium hydroxide solution (10N). The product was collected by filtration and dried to give 2-(4-chlorobenzoyl)hydrazinecarboximidamide as a white solid (2.1 g, crude).

Fuente