Reacción #1010517

Ecuación de reacción

isobutyric acid

hydrazinecarboximidamide carbonic acid salt

HNO3

→

3-isopropyl-1H-1,2,4-triazol-5-amine

Rendimiento 65.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe resulting mixture was concentrated under vacuum

Procedimiento

To a solution of isobutyric acid (25 g, 283.75 mmol) in water (25 mL) was added hydrazinecarboximidamide carbonic acid salt (15 g, 110.29 mmol) and HNO3 (0.3 mL), and the reaction mixture was stirred for 75 h at 110° C. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column (dichloromethane/methanol (15:1)) to afford 3-isopropyl-1H-1,2,4-triazol-5-amine as a white solid (9 g, 65%).

Fuente