Reacción #1009295

Ecuación de reacción

(5-bromo-2-methylphenyl)acetic acid

thionyl chloride

→

title compound

(5-Bromo-2-methylphenyl)acetyl chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated under reduced pressure
2. 2
   OtroDrying under fine vacuum

Procedimiento

6.00 g (26.19 mmol) of (5-bromo-2-methylphenyl)acetic acid (EP 1791816 A1 and US 2006/29799 A1) were dissolved in 31.20 g (261.92 mmol) of thionyl chloride. The reaction mixture was stirred at 80° C. for two hours and then concentrated under reduced pressure. Drying under fine vacuum gave 6.29 g (97% of theory) of the title compound as a brownish oil.

Fuente