Reacción #1005957

Ecuación de reacción

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

Rendimiento 95.2%

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted twice with ethyl acetate
2. 2
   Lavadowashed with water
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   FiltraciónThe desiccant was filtered
5. 5
   Otroseparated
6. 6
   Otrothe solvent was evaporated off under reduced pressure

Procedimiento

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

Fuente