Reacción #1002000

Ecuación de reacción

7-(tert-butoxycarbonyl)-2-hydroxy-7-azaspiro[3.5]nonane

methanesulfonyl chloride

→

title compound

Rendimiento 100.0%

7-(tert-Butoxycarbonyl)-2-methanesulfonyloxy-7-azaspiro[3.5]nonane

Rendimiento 100.0%

Disolventes

tetrahydrofuran

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   FiltraciónThe reaction mixture was filtered
3. 3
   Concentraciónthe filtrate was concentrated under reduced pressure
4. 4
   workup.ADDITIONAfter adding water
5. 5
   Extracciónto the residue, extraction
6. 6
   LavadoThe organic layer was washed with water
7. 7
   Secadodried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedimiento

After dissolving 106 mg of 7-(tert-butoxycarbonyl)-2-hydroxy-7-azaspiro[3.5]nonane in 10 ml of tetrahydrofuran, 0.04 ml of methanesulfonyl chloride and 0.07 ml of triethylamine were added and the mixture was stirred overnight at room temperature. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. After adding water to the residue, extraction was performed with ethyl acetate. The organic layer was washed with water and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (148 mg, 100% yield).

Fuente