Reacción #1001836

Ecuación de reacción

compound 10

Diethyl 2-(2-tert-butyloxycarbonyl ethyl)malonate

TFA

→

compound 11

Rendimiento 100.0%

Diethyl 2-(2-carboxyethyl)malonate

Rendimiento 100.0%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture is concentrated under vacuum

Procedimiento

To a solution of compound 10 (19.6 g, 68.05 mmol), in 400 mL CH2Cl2 is added 400 mL of TFA. The mixture is stirred under during 48 h at room temperature. The reaction mixture is concentrated under vacuum, coevaporated two times with cyclohexane to eliminate excess TFA yielded 15.8 g compound 11 as oil used without further purification.

Fuente