Reacción #1001823

Ecuación de reacción

1-tert-butoxycarbonylamino-3-[2-(12-carboxy-1,1,2,2-tetrafluoro-4-iodododecyloxy)-1,1,2,2-tetrafluoroethanesulfonyloxy]-cyclobutane carboxylic acid methyl ester

acetic acid

→

1-tert-butoxycarbonylamino-3-[2-(12-carboxy-1,1, 2,2-tetrafluorododecyloxy)-1,1,2,2-tetrafluoroethanesulfonyloxy]-cyclobutane carboxylic acid methyl ester

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated
2. 2
   Temperaturaat reflux for 1 hour
3. 3
   TemperaturaThe mixture was cooled
4. 4
   Otrothe solvent decanted off
5. 5
   OtroThe solvent was removed at reduced pressure at ambient pressure

Procedimiento

To the solution of 1-tert-butoxycarbonylamino-3-[2-(12-carboxy-1,1,2,2-tetrafluoro-4-iodododecyloxy)-1,1,2,2-tetrafluoroethanesulfonyloxy]-cyclobutane carboxylic acid methyl ester in diethyl ether was added an excess of zinc metal followed-by acetic acid. The mixture was heated at reflux for 1 hour. The mixture was cooled and the solvent decanted off taking care no zinc metal passed out of the reaction vessel. The solvent was removed at reduced pressure at ambient pressure.

Fuente