barbituric acid

O=c1cc[nH]c(=O)n1Cl
Reaction #44421
Chlorouracil
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06
O=C1NC(=O)C(=Cc2cc(Br)cc(Br)c2O)C(=O)N1
Reaction #84047
product 1a
Rendimiento 84.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2016_09
N#CCC(=O)NCCNC(=O)CC#N
Reaction #215540
bis-cyanoacetylethylenediamine
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-1981_03
CCCC1CN2c3ccc([N+](=O)[O-])cc3CC3(C(=O)NC(=O)NC3=O)C2C(C)O1
Reaction #246010
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
CC(=O)c1cc2c(c(F)c1F)N1C[C@@H](C)O[C@@H](C)[C@@H]1C1(C2)C(=O)NC(=O)NC1=O
Reaction #332541
title compound
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(N)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332728
title compound
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
Cc1noc2c(F)c3c(cc12)CC1(C(=O)NC(=O)NC1=O)[C@H]1[C@H](C)O[C@H](C)CN31
Reaction #332730
title compound
Rendimiento 71.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
Cc1noc2c(Cl)c3c(cc12)CC1(C(=O)NC(=O)NC1=O)[C@H]1[C@H](C)O[C@H](C)CN31
Reaction #332733
(2R,4S,4aS)-rel-11-chloro-2,4,8-trimethyl-1,2,4,4a-tetrahydro-2′H,6H-spiro[1,4-oxazino[4,3-a][1,2]oxazolo[4,5-g]quinoline-5,5′-pyrimidine]-2′,4′,6′(1′H,3′H)-trione
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(-n5cncn5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332734
product
Rendimiento 43.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(-c5nc(C(=O)N6CCOCC6)cs5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332735
TFA
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(C(=O)NCC(F)F)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332736
(2R,4S,4aS)-rel-N-(2,2-difluoroethyl)-11-fluoro-2,4-dimethyl-2′,4′,6′-trioxo-2,2′,3′,4,4a,4′,6,6′-octahydro-1H,1′H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5′-pyrimidine]-8-carboxamide
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(C(=O)N5CC(F)(F)C5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332737
title compound
Rendimiento 81.5%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(-c5nccs5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332738
title compound
Rendimiento 71.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(-c5ccco5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332739
title compound
Rendimiento 85.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(OC(=O)OC(C)(C)C)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332740
tert-butyl (2R,4S,4aS)-rel-11-fluoro-2,4-dimethyl-2′,4′,6′-trioxo-1,1′,2,3′,4,4′,4a,6′-octahydro-2′H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5′-pyrimidin]-8-yl carbonate
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
Cc1ncc(-c2noc3c(Cl)c4c(nc23)CC2(C(=O)NC(=O)NC2=O)[C@H]2[C@H](C)O[C@H](C)CN42)s1
Reaction #332742
title compound
Rendimiento 13.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(-c5cnccn5)noc4c3Cl)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332743
(2R,4S,4aS)-rel-11-chloro-2,4-dimethyl-8-(pyrazin-2-yl)-2,4,4a,6-tetrahydro-1H,1′H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5′-pyrimidine]-2′,4′,6′(3′H)-trione
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
Cc1noc2c(Cl)c3c(nc12)CC1(C(=O)NC(=O)NC1=O)[C@H]1[C@H](C)O[C@H](C)CN31
Reaction #332744
yellow solid
Rendimiento 42.7%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
CCOC(=O)c1noc2c(F)c3c(cc12)CC1(C(=O)NC(=O)NC1=O)[C@H]1[C@H](C)O[C@H](C)CN31
Reaction #332745
title compound
Rendimiento 89.5%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
C[C@@H]1CN2c3c(cc4c(-c5cnccn5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
Reaction #332746
(2R,4S,4aS)-rel-11-fluoro-2,4-dimethyl-8-(pyrazin-2-yl)-1,2,4,4a-tetrahydro-2′H,6H-spiro[1,4-oxazino[4,3-a][1,2]oxazolo[4,5-g]quinoline-5,5′-pyrimidine]-2′,4′,6′(1′H,3′H)-trione
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02
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