Reaction #993

Reaction equation

Chloroacetylchloride

2-aminopyridine

diisopropylethylamine

→

brown solid

Yield 80.1%

2-Chloro-N-(2-pyridinyl)acetamide

Yield 80.1%

Solvents

dichloromethane

Conditions

Workup

1. 1
   Otherthe temperature below 5° C
2. 2
   Filtrationwas filtered
3. 3
   Washwashed with water
4. 4
   DryingThe organic layer was dried (MgSO4)
5. 5
   Otherevaporated under reduced pressure

Procedure

Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.

Source