Reaction #985311

Reaction equation

4-Diethoxymethyl-2-hexylsulfanyl-pyrimidine

HCl

Na2CO3

→

2-Hexylsulfanyl-pyrimidine-4-carbaldehyde

Solvents

THF

Conditions

Workup

1. 1
   Extractionextracted twice with AcOEt and once with sat. NaCl solution

Procedure

4-Diethoxymethyl-2-hexylsulfanyl-pyrimidine (250 mg, 0.8 mmol) was stirred in THF (5 mL) and 4 N HCl (5 mL) at 20° C. for 64 h. The reaction mixture was poured in cold 10% Na2CO3 and extracted twice with AcOEt and once with sat. NaCl solution.

Source