Reaction #985299

Reaction equation

Thiourea

1-bromohexane

→

white crystals

Yield 91.2%

2-Hexyl-isothiourea hydrobromide

Yield 91.2%

Solvents

ethanol

Conditions

Workup

1. 1
   OtherEthanol was evaporated
2. 2
   OtherThe product precipitated spontaneously
3. 3
   FiltrationAfter filtration one

Procedure

Thiourea (50 g, 657 mmol) and 1-bromohexane (119 mL, 723 mmol) were heated at reflux under nitrogen in ethanol (500 mL) for 20 h. Ethanol was evaporated, and the thick oil stirred in diethyl ether (500 mL). The product precipitated spontaneously. After filtration one obtained 144.5 g (91%) of white crystals, m.p. 75° C.

Source