Reaction #985262

Reaction equation

2-(4-nitrophenyl)benzothiazole

tin (II) chloride dihydrate

→

2-(4-Aminophenyl)benzothiazole

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturewas refluxed under N2 for 4 hrs
2. 2
   OtherAfter removing ethanol
3. 3
   Otherby vacuum evaporation
4. 4
   workup.DISSOLUTIONThe residue was dissolved into ethyl acetate (20 ml)
5. 5
   Washwashed with NaOH solution (1 N, 3×20 ml) and water (3×20 ml)
6. 6
   Otherdried
7. 7
   Otherevaporated to dryness to givelo2 mg (97%) of the product

Procedure

A mixture of 2-(4-nitrophenyl)benzothiazole (105 mg, 0.40 mmol) and tin (II) chloride dihydrate (205 mg, 0.91 mmol) in ethanol (20 mL) was refluxed under N2 for 4 hrs. After removing ethanol by vacuum evaporation. The residue was dissolved into ethyl acetate (20 ml), and washed with NaOH solution (1 N, 3×20 ml) and water (3×20 ml), dried and evaporated to dryness to givelo2 mg (97%) of the product

Source