Reaction #985258

Reaction equation

p-Anisidine

pyridine

4-nitrobenzoyl chloride

water

→

4-Methoxy-4′-nitrobenzanilide

Conditions

Workup

1. 1
   Otherthe precipitate was collected with filtrate under vacuum pressure
2. 2
   Washwashed with 5% sodium bicarbonate (2×10 ml)
3. 3
   OtherThe product 3 was used in the next step without further purification

Procedure

p-Anisidine 1 (1.0 g, 8.1 mmol) was dissolved in anhydrous pyridine (15 ml), 4-nitrobenzoyl chloride 2 (1.5 g, 8.1 mmol) was added. The reaction mixture was allowed to stand at room temperature for 16 hrs. The reaction mixture was poured into water and the precipitate was collected with filtrate under vacuum pressure and washed with 5% sodium bicarbonate (2×10 ml). The product 3 was used in the next step without further purification.

Source