Reaction #9743

ord-ae8b6db692d04441a65dd7b35c322628

Reaction equation

CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
intermediate 43
CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
ethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
CC(C)S
isopropylthiol
→
CC(C)SCc1cc(-c2ccc(C(F)(F)F)cc2)sc1CO
{3-[(isopropylthio)methyl]-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

Reactants

CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
intermediate 43
CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
ethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
CC(C)S
isopropylthiol

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared from intermediate 43 and isopropylthiol

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091237B2uspto-grants-2006_08