Reaction #9742

ord-2e95888c3ff84a0fb8e3c2a881c4f9d9

Reaction equation

CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
intermediate 43
CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
ethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
Oc1ccccc1
phenol
→
OCc1sc(-c2ccc(C(F)(F)F)cc2)cc1COc1ccccc1
{3-(phenoxymethyl)-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

Reactants

CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
intermediate 43
CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
ethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
Oc1ccccc1
phenol

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared from intermediate 43 and phenol

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091237B2uspto-grants-2006_08