Reaction #956696

Reaction equation

2-(3,3-difluorocyclobutyl)-1H-benzo[d]imidazole

(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

→

title compound

Yield 96.9%

(E)-2-(8-{[2-(3,3-difluorocyclobutyl)-1H-benzo[d]imidazol-1-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile

Yield 96.9%

Conditions

Workup

1. 1
   Otherobtained in Reference Example 1

Procedure

[step 3] Using 2-(3,3-difluorocyclobutyl)-1H-benzo[d]imidazole (57 mg, 0.27 mmol) obtained in step 2 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (100 mg, 0.28 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (127 mg, 96%) was obtained.

Source