Reaction #955933

Reaction equation

methyl 2,4-dimethylbenzoate

hydrazine

→

2,4-dimethylbenzohydrazide

Solvents

MeOH

Conditions

Workup

1. 1
   Temperaturethe mixture was heated
2. 2
   Temperatureunder reflux for 40 hours
3. 3
   OtherThen the mixture was evaporated
4. 4
   Otherdried under vacuum

Procedure

To a solution of methyl 2,4-dimethylbenzoate (2 g, 12.2 mmol) in MeOH (10 mL) was added anhydrous hydrazine (1.95 mL, 61 mmol) and the mixture was heated under reflux for 40 hours. Then the mixture was evaporated and dried under vacuum to give 2,4-dimethylbenzohydrazide as a white solid (2 g, 100%; MS (M+H, 165).

Source