Reaction #95223

Reaction equation

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,4-dichlorobenzoyl chloride

→

pure product

Yield 69.5%

5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Yield 69.5%

Solvents

xylene

Conditions

Workup

1. 1
   ConcentrationThe reaction mixture was concentrated in vacuo
2. 2
   Extractionthe resulting residue extracted with benzene
3. 3
   workup.ADDITIONAddition of hexane

Procedure

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

Source