Reaction #95218

Reaction equation

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-nitrobenzoyl chloride

→

pure product

Yield 73.5%

5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Yield 73.5%

Solvents

toluene

Conditions

Workup

1. 1
   Temperatureat reflux for 20 hours
2. 2
   Otherthe crude product precipitated from the reaction mixture
3. 3
   Otherwas isolated by filtration
4. 4
   WashAfter washing with hexane

Procedure

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

Source