Reaction #94600

Reaction equation

α-chloromethyl-2-methoxybenzylalcohol

potassium hydroxide

→

2-(2-methoxyphenyl)oxirane

Yield 44.4%

Solvents

dioxane

water

Conditions

Workup

1. 1
   Extractionthe aqueous mixture is extracted with benzene
2. 2
   OtherThe extract is dried
3. 3
   Otherevaporated
4. 4
   Otherto remove solvent

Procedure

1.4 g of α-chloromethyl-2-methoxybenzylalcohol (crude oil) are dissolved in 12 ml of dioxane, and a solution of 840 mg of potassium hydroxide in 5 ml of water is added thereto. The mixture is stirred at room temperature for 3 hours. Then, the reaction mixture is poured into ice-water, and the aqueous mixture is extracted with benzene. The extract is dried and evaporated to remove solvent. 0.5 g of 2-(2-methoxyphenyl)oxirane are obtained as a crude product.

Source