Reaction #94598

Reaction equation

hydrochloric acid

α-chloromethyl-2-methoxybenzylalcohol

3,4-dimethoxyphenethylamine

chloroform

→

α-(3,4-dimethoxyphenethylaminomethyl)-2-methoxybenzylalcohol hydrochloride

Yield 41.1%

Solvents

ethanol

diethylether

Conditions

Workup

1. 1
   Temperatureis heated at 130° to 140° C. for 2 hours
2. 2
   TemperatureAfter cooling
3. 3
   Washis washed with water
4. 4
   OtherThe mixture is dried
5. 5
   Otherevaporated
6. 6
   Otherto remove solvent
7. 7
   workup.ADDITION30 ml of ethanol are added to the residue
8. 8
   Otherobtained
9. 9
   Othercrystalline precipitates
10. 10
    Filtrationare collected by filtration

Procedure

A mixture of 3.7 g of α-chloromethyl-2-methoxybenzylalcohol (crude oil) and 10.9 g of 3,4-dimethoxyphenethylamine is heated at 130° to 140° C. for 2 hours. After cooling, chloroform is added to the reaction mixture, and said mixture is washed with water. The mixture is dried and evaporated to remove solvent. 30 ml of ethanol are added to the residue obtained. Then, hydrochloric acid-containing diethylether is added to the ethanol mixture, and crystalline precipitates are collected by filtration. 3.0 g of α-(3,4-dimethoxyphenethylaminomethyl)-2-methoxybenzylalcohol hydrochloride are obtained as crystals. M.p. 142°-143° C.

Source