Reaction #944004

Reaction equation

4-difluoromethoxybenzaldehyde

4-methylthioaniline

→

N-(4-difluoromethoxybenzylidene)-4-methylthioaniline

Yield 91.0%

Conditions

Procedure

Following a procedure similar to that described in Example 1(i), but using 4-difluoromethoxybenzaldehyde and 4-methylthioaniline as starting materials, N-(4-difluoromethoxybenzylidene)-4-methylthioaniline was obtained in a yield of 91%. This aniline compound and trimethylsilyl cyanide were then reacted together in a similar manner to that described in Example 1(ii), to give the title compound as a slightly yellow powder (yield 80%).

Source