Reaction #94242

Reaction equation

4-hydroxy-4-phenylpiperidine hydrochloride

acetone

paraformaldehyde

nitromethane

→

4-(4-hydroxy-4-phenypiperidino)-2-butanone hydrochloride

Solvents

cyclohexane

Conditions

Workup

1. 1
   OtherThe starting material is prepared
2. 2
   Otherthe precipitate collected

Procedure

The starting material is prepared as follows: The solution of 20 g of 4-hydroxy-4-phenylpiperidine hydrochloride, 10 ml of acetone, 5.6 g of paraformaldehyde and 100 ml of nitromethane is refluxed for 12 hours. It is diluted with 500 ml of cyclohexane and the precipitate collected, to yield the 4-(4-hydroxy-4-phenypiperidino)-2-butanone hydrochloride.

Source