Reaction #929

Reaction equation

2,6-dinitrobenzonitrile

thiophenol

K2CO3

Pyridine

→

2-nitro-6-(phenylthio)benzonitrile

Yield 89.0%

Solvents

H2O

DMF

Conditions

Workup

1. 1
   FiltrationThe yellow precipitate was collected by filtration
2. 2
   Washwashed with 1N NaOH, water
3. 3
   Otherdried

Procedure

An ice water bath-cooled mixture of 2.0 g (0.01 mol) of 2,6-dinitrobenzonitrile (Lancaster Synthesis, Inc., Windham, N.H. 03087), 1.06 ml (0.01 mol) of thiophenol, and 1.44 g (0.01 mol) of anhydrous K2CO3 in 50 mL of DMF was stirred for 0.5 h. Pyridine was added to the reaction mixture until it became basic, and was followed by the addition of approximately 100 mL of H2O. The yellow precipitate was collected by filtration, washed with 1N NaOH, water and dried to give 1.94 g (89%) of 2-nitro-6-(phenylthio)benzonitrile as a yellow solid: mp 106°-107° C.

Source