Reaction #927279

Reaction equation

N-{3-amino-4-(3,5-bis-trifluoromethyl-benzylamino)-phenyl}-benzenesulphonamide

p-cyano-phenylpropionic acid

ethyl acetate diethylether

→

N-{2-[2-(4-Cyanophenyl)-ethyl]-1-(3,5-bis-trifluoromethyl-benzyl)-benzimidazol-5-yl}-benzenesulphonamide

Solvents

POCl3

Conditions

Workup

1. 1
   OtherA precipitate settles out from the initially clear solution in the course of the reaction
2. 2
   TemperatureAfter cooling it
3. 3
   FiltrationThe crystals are filtered off
4. 4
   Washwashed with diethylether

Procedure

N-{3-amino-4-(3,5-bis-trifluoromethyl-benzylamino)-phenyl}-benzenesulphonamide (5.5 g, 11.2 mmol) and p-cyano-phenylpropionic acid (2.35 g, 13.4 mmol) are taken up in 50 mL POCl3, and stirred for 2 h at 100-120° C. A precipitate settles out from the initially clear solution in the course of the reaction. After cooling it is diluted with 100 mL ethyl acetate/diethylether=1/1. The crystals are filtered off and washed with diethylether.

Source