Reaction #927238

ord-7bf0b9edf94a422fbfe95b302b47f93e

Reaction equation

C#CCN
Propargylamine
COC(=O)C(F)(F)F
methyl trifluoroacetate
→
C#CCNC(=O)C(F)(F)F
N-propargyltrifluoroacetamide
Yield 86.0%

Reactants

C#CCN
Propargylamine
COC(=O)C(F)(F)F
methyl trifluoroacetate

Reagents

None

Conditions

Temperature
0°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherto react at 0° C. for two hours

Procedure

Propargylamine (Aldrich, 25 g, 0.45 mol) was added dropwise to methyl trifluoroacetate (Tokyo Chemical Industry Co., Ltd., 69.2 g, 0.54 mol) cooled to 0° C. They were allowed to react at 0° C. for two hours to afford 43.8 g (86.0%) of N-propargyltrifluoroacetamide after purification by vacuum distillation (23 mmHg, boiling point; 77° C.).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06365350B1uspto-grants-2002_04