Reaction #9182

Reaction equation

7-bromo-heptanoic acid benzyloxy-amide

benzo[cd]indol-2(1H)-one

potassium carbonate

→

7-(2-oxo-2H-benzo[cd]indol-1-yl)-heptanoic acid benzyloxyamide

Conditions

Procedure

In a manner analogous to that of example 2(b), 7-bromo-heptanoic acid benzyloxy-amide 0.46 g, 1.5 mmol) was reacted with benzo[cd]indol-2(1H)-one (0.25 g, 1.5 mmol) in the presence of potassium carbonate (0.2 g, 1.4 mmol) to give 7-(2-oxo-2H-benzo[cd]indol-1-yl)-heptanoic acid benzyloxyamide as an amorphous solid (yield 0.08 g, 13%; purified by column chromatography using silica gel and ethyl acetate:heptane=1:1 as an eluent). MS (M+H+)=403.

Source