Reaction #9173

ord-8282e8e7abbb474d9be6f23017c76a92

Reaction equation

Fc1ccc(-c2cc3ccccc3[nH]2)cc1
2-(4-fluoro-phenyl)-1H-indole
C[N+](C)=Cc1cccc(Oc2ccccc2)c1.[Cl-]
(3-phenoxy-benzylidene)-dimethylammonium chloride
O=Cc1cccc(Oc2ccccc2)c1
3-phenoxy-benzaldehyde
CNC
dimethylamine
→
CN(C)C(c1cccc(Oc2ccccc2)c1)c1c(-c2ccc(F)cc2)[nH]c2ccccc12
[[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-dimethyl-amine

Reactants

Fc1ccc(-c2cc3ccccc3[nH]2)cc1
2-(4-fluoro-phenyl)-1H-indole
C[N+](C)=Cc1cccc(Oc2ccccc2)c1.[Cl-]
(3-phenoxy-benzylidene)-dimethylammonium chloride
O=Cc1cccc(Oc2ccccc2)c1
3-phenoxy-benzaldehyde
CNC
dimethylamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 2-(4-fluoro-phenyl)-1H-indole and (3-phenoxy-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 3-phenoxy-benzaldehyde and dimethylamine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091220B2uspto-grants-2006_08