Reaction #90807

Reaction equation

5-[4-(2-hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide

5-[4-(2-Hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide

→

2-amino-5-[4-(2-Hydroxyethyl)-1-piperazinyl]-N-methylbenzamide

Solvents

MeOH

MeOH CH2Cl2

Conditions

Workup

1. 1
   FiltrationThe resulted mixture was filtered
2. 2
   Otherto get rid of the Pd catalyst
3. 3
   Otherthe residue was used without further purification

Procedure

A solution of 5-[4-(2-hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide 3 in 250 mL of MeOH in a 250 mL round bottom flask was stirred at room temperature under hydrogen balloon over night. The resulted mixture was filtered to get rid of the Pd catalyst. TLC in 10% MeOH/CH2Cl2 showed no more starting material and a major product. The solvent was rotavaped to dryness, and the residue was used without further purification. MS(ES) m/e 279 [M+H].

Source