Reaction #9029

Reaction equation

2,2,2-trifluoro-1-piperazin-1-yl-ethanone

allyl bromide

potassium carbonate

→

piperazine

Yield 155.1%

1-allyl-piperazine

Yield 155.1%

Solvents

CH3CN

Conditions

Workup

1. 1
   ConcentrationThe reaction was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with CH2Cl2 (30 mL) and water (30 mL)
3. 3
   Extractionthe aqueous layer extracted with CH2Cl2 (2×20 mL)
4. 4
   DryingThe combined organic extracts were dried (Na2SO4)
5. 5
   Filtrationfiltered
6. 6
   Concentrationconcentrated in vacuo

Procedure

To a stirred solution of 2,2,2-trifluoro-1-piperazin-1-yl-ethanone (515 mg, 2.83 mmol) in dry CH3CN (6 mL) was added allyl bromide (0.32 mL, 3.7 mmol) and powdered potassium carbonate (0.78 g, 5.65 mmol) and the mixture stirred overnight. The reaction was concentrated under reduced pressure, diluted with CH2Cl2 (30 mL) and water (30 mL) and the aqueous layer extracted with CH2Cl2 (2×20 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated in vacuo to afford the crude di-protected piperazine (0.554 g) which was used without further purification in the next reaction.

Source