Reaction #901

Reaction equation

nitric acid

2-methyl-6-acetamidobenzoic acid

→

2-Methyl-3-nitro-6-acetamidobenzoic acid

Solvents

water

Conditions

Workup

1. 1
   Otherare initially taken at -5° C.
2. 2
   workup.ADDITIONare added in portions
3. 3
   FiltrationThe deposited precipitate is filtered off with suction
4. 4
   Washwashed with water
5. 5
   Otherdried under reduced pressure at 50° C.

Procedure

271 ml of 98% nitric acid are initially taken at -5° C. and 106 g (0.55 mol) of the 2-methyl-6-acetamidobenzoic acid prepared in 1. are added in portions. After stirring at 10° C. for one hour, the reaction mixture is poured into a mixture of 540 g of ice and 270 ml of water. The deposited precipitate is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

Source