Reaction #90091
ord-3ff0c68ac71a4ed383672c34660ff6b8
Reaction equation
Phosphorus pentoxide methanesulfonic acid
2-[1-(3-bromo-4-methoxy-phenyl)-1-methyl-ethyl]-6-cyano-1H-indole-3-carboxylic acid ethyl ester
water
→
title compound
Yield 85.0%
8-Bromo-9-methoxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Yield 85.0%
Reactants
Reagents
None
Solvents
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1Filtrationthe precipitated solid was filtered
Procedure
Phosphorus pentoxide-methanesulfonic acid (12 mL) was added with 2-[1-(3-bromo-4-methoxy-phenyl)-1-methyl-ethyl]-6-cyano-1H-indole-3-carboxylic acid ethyl ester (Compound K5, 1.0 g, 2.27 mmol), and the mixture was stirred at room temperature for 20 min. The reaction solution was diluted with MeCN (20 mL), poured into water (20 mL), and the precipitated solid was filtered to obtain the title compound (yellow solid, 763 mg, 85%).