Reaction #8976

ord-3ee0bb3ddc264ecaac4ee315d3cd79dd

Reaction equation

Cc1cc(C#Cc2c[nH]c(C)n2)ccn1
2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine
FC(F)CBr
2-bromo-1,1-difluoro ethane
Cc1cc(C#Cc2cn(CC(F)F)c(C)n2)ccn1
title compound
Cc1cc(C#Cc2cn(CC(F)F)c(C)n2)ccn1
4-[1-(2,2-Difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound, MS: m/e=262.1 (M+H+), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2-bromo-1,1-difluoro ethane.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091222B2uspto-grants-2006_08