Reaction #89108

ord-859d49219113445987c5fbc547119079

Reaction equation

Cc1nc(C(=O)O)c(-c2ccc(F)cc2)s1
5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid
CCOC1(OCC)CCC(CO)NC1
rac-(5,5-diethoxypiperidin-2-yl)methanol
→
CCOC1(OCC)CCC(CO)N(C(=O)c2nc(C)sc2-c2ccc(F)cc2)C1
title compound
CCOC1(OCC)CCC(CO)N(C(=O)c2nc(C)sc2-c2ccc(F)cc2)C1
rac-(5,5-Diethoxy-2-(hydroxymethyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Reactants

Cc1nc(C(=O)O)c(-c2ccc(F)cc2)s1
5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid
CCOC1(OCC)CCC(CO)NC1
rac-(5,5-diethoxypiperidin-2-yl)methanol

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared according to general procedure A using 5-(4-fluorophenyl)-2-methylthiazole-4-carboxylic acid and rac-(5,5-diethoxypiperidin-2-yl)methanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09440982B2uspto-grants-2016_09