Reaction #87602

Reaction equation

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

Solvents

methanol

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was refluxed for 18 h
2. 2
   ConcentrationThe reaction mixture was concentrated
3. 3
   Othercrude reaction mixture

Procedure

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

Source